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The kidney is a complex organ that filters blood. Urine is a filtrate of this blood and is produced in microscopic units called glomeruli. This urine then flows through tubules into larger structures called calyces. The calyces form a renal pelvis, which is connected to the bladder by a long tube called ureter.
Renal tubules are specialized cells that select from the fluid in the kidney, including urine and blood, for reabsorption or secretion. Abnormalities of these processes cause tubulopathies, a group of diseases that include renal multicystic dysplasia and medullary cystic disease.
Symptoms of tubulointerstitial diseases vary from person to person. Some people have no symptoms and may never develop them. Others have a variety of symptoms, such as fever, pain in the back or side (flank), and changes in urinary frequency and urgency.
Acute interstitial nephritis is often caused by an allergic reaction to a drug; other causes include infection or systemic disease such as cancer. Most acute interstitial nephritis responds quickly to medication and is usually cured.
Chronic interstitial nephritis may develop slowly over time, causing kidney damage that eventually requires dialysis or a kidney transplant. Early detection of the illness and prompt discontinuation of the offending medication are essential to prevent kidney failure or death.